Tau, APP, NCT and BACE1 in lymphocytes through cognitively normal ageing and neuropathology
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چکیده
منابع مشابه
Tau, APP, NCT and BACE1 in lymphocytes through cognitively normal ageing and neuropathology.
Although Alzheimer's disease is a brain disorder, a number of peripheral alterations have been found in these patients; however, little is known about how the key genes involved in the pathophysiology express in peripheral cells such as lymphocytes during normal compared to neuropathological ageing. We analysed the expression of tau, of the amyloid precursor protein, of nicastrin and of the β-s...
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Introduction: Alzheimer's disease is a progressive brain disorder, which slowly eliminates memory and intellectual ability and eventually destroys the ability to carry out the simple tasks. β amyloid plaque and neurofibrillary tangles are two important signatures of this disease, which caused by mutant in Tau, BACE1, and APP genes. They could be important targets for treatment of Alzheimer's di...
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ژورنال
عنوان ژورنال: Anais da Academia Brasileira de Ciências
سال: 2013
ISSN: 0001-3765
DOI: 10.1590/0001-376520130013